​​Selected Publications:

• Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC. (2020) Nat Commun.;11(1):2086.

• Pulsatile MAPK signalling modulates p53 activity to control cell fate decisions at the G2 checkpoint for DNAdamage. De, S, Campbell, C, Venkitaraman, AR*, Esposito, A* (2020) CellRep (* Joint seniorauthor).

• A systems view of spliceosomal assembly and branchpoints with iCLIP. Briese M, Haberman N, Sibley CR, Faraway R, Elser AS,Chakrabarti AM, Wang Z, König J, Perera D, Wickramasinghe VO, Venkitaraman AR, Luscombe NM, Saieva L, Pellizzoni L,Smith CWJ, Curk T, Ule J. (2019) Nature Struct Mol Biol 26, 930-40.

• Enhancing biochemical resolution by hyper dimensional imaging microscopy. Esposito A., VenkitaramanA.R. (2019). Biophys J. 116, 1815-22.

• Structure guided synthesis and evaluation of small molecule inhibitors targeting protein-protein interactions of BRCA1 tBRCTdomain. Kurdekar V, Giridharan S, Subbarao J, Nijaguna MB, Periasamy J, Boggaram S, Shivange AV, Sadasivam G, Padigaru M, Potluri V, Venkitaraman AR, Bharatham K. (2019) ChemMedChem 14, 1620-23.

• BRCA2 regulates transcription elongation by RNA polymeraseII to prevent R-loop accumulation. Shivji, M.K., Renaudin, X., Williams, C., Venkitaraman, A.R. (2018) Cell Rep 22,1031-39.

• Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Periasamy J, Kurdekar V, Jasti S, Nijaguna MB, Boggaram S, Hurakadli MA, Raina D, Kurup LM, Chintha C, Manjunath K, Goyal A, Sadasivam G, Bharatham K, Padigaru M, Potluri V, Venkitaraman AR. (2018) Cell Chemical Biology 25: p. 1–14.
• Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions. Laraia, L., G. McKenzie, D.R. Spring, A.R. Venkitaraman, and D.J. Huggins. (2015) Cell Chem Biol. 22: p. 689-703.
• Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength. Wickramasinghe, V.O., M. Gonzalez-Porta, D. Perera, A.R. Bartolozzi, C.R. Sibley, M.Hallegger, J. Ule, J.C. Marioni, and A.R. Venkitaraman. (2015) Genome Biol. 16: p. 201
• Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.Venkitaraman, A.R. Science (2014) 343(6178):1470-5.
• Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing. Liang H, Esposito A, De S, Ber S, Collin P, Surana U, Venkitaraman AR. Nature Commun (2014) 5:4048.
• Diversity-oriented synthesis as a tool for identifying new modulators of mitosis. Ibbeson B.M., Laraia L., Alza E, O' Connor C.J., Tan Y., Davies H.M., McKenzie G., Venkitaraman A.R.*, Spring D.* Nature Commun. (2014) 5:3155.
• A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Jeyasekharan, A.D., Liu, Y., Hattori, H., Pisupati, V., Jonsdottir, A.B., Rajendra, E., Lee, M., Sundaramoorthy, E., Schlachter, S., Kaminski, C., Rosenfeld, Y., Sato, K., Savill, J., Ayoub, N.&Venkitaraman, A.R. Nature Str Mol Biol. (2013). 20, 1191-8.
• Human inositol polyphosphate kinase regulates transcript-selective nuclear mRNA export to preserve genome integrity.Wickramasinghe, V., Savill, J. Chavali, S., Jonsdottir, A.B., Rajendra, E., Gruner, T., Laskey, R., Babu, M., &Venkitaraman, A.R. (2013). Molecular Cell. 51, 737-43.
• Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis. Mahen, R., Jeyasekharan, A.D., Barry, N.P., and Venkitaraman, A.R. Proc Natl Acad Sci (2011). USA 108, 9310-9315.
• Germline BRCA2 heterozygosity promotes KrasG12D–driven carcinogenesis in a murine model of familial pancreatic cancer.Skoulidis, F., Cassidy, L., Pisupati, V., Jonasson, J., Eyfjord, J., Kerreth, F., Lim, M., Olive, K. Tuveson, D. &Venkitaraman, A. R. Cancer Cell (2010) 18, 499-509.
• The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Shivji, M. K., Mukund, S. R., Rajendra, E., Chen, S., Short, J. M., Savill, J., Klenerman, D., and Venkitaraman, A. R. Proc Natl Acad Sci USA (2009). 106, 13254-13259
• UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. Garnett, M., Mansfeld, J., Godwin, C., Matsusaka, T., Wu, J., Russell, P., Pines, J. &Venkitaraman, A. R. Nature Cell Biol (2009). 11, 1363-69.
• HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Ayoub N.A., A.D. Devaprasath, J.A. Bernal & A.R. Venkitaraman Nature (2008). 453: 682-6.