Dr. Ravi Muddashetty
Activity mediated protein synthesis is a fundamental aspect of all multicellular systems. My lab is interested in understanding the regulation of activity mediated protein synthesis in nervous system during neuronal development and plasticity. While the signaling cascades are responsible for sensing and interpreting the external milieu, the actual regulation of translation is heavily ‘RNA centric’ and is conducted by specific RNA binding proteins which acts as ‘molecular switches’ These RNA binding proteins and the pathways regulated by them are critical in neuronal development and are at the heart of many neurodevelopmental disorders. Our approach is to understand the function of these RNA binding proteins and attempt to unravel the mechanism synaptic protein synthesis.