Research at inStem addresses complex problems in areas of cell-differentiation and tissue regeneration using human pluripotent cells, examines clinical manifestations of diseases that can potentially be treated by stem cells, models human diseases using stem cells, uses model organisms to address fundamental questions in regenerative biology, develops platforms to interrogate signaling pathways with new chemical entities, and finally, develops tools that will help to better understand the biology driving stem cells and eventually treat disease states. Research is carried out by groups who work on tightly-knit themes, crossing boundaries and developing new approaches to address questions larger than the expertise of the individual laboratory.