TitleAnti-cancer Application of Nat-ZnFeO Nanoparticles on 2D Tumor Models.
Publication TypeJournal Article
Year of Publication2024
AuthorsChabattula SChander, Patra B, Gupta PKumar, Govarthanan K, Rayala SKumar, Chakraborty D, Verma RShanker
JournalAppl Biochem Biotechnol
Date Published2024 Feb
KeywordsAnimals, Anti-Bacterial Agents, Humans, Metal Nanoparticles, Mice, nanoparticles, Neoplasms, Oxides, Plant Extracts, Zinc, Zinc Oxide

Metal/Metal Oxide nanoparticles (M/MO NPs) exhibit potential biomedical applications due to their tunable physicochemical properties. Recently, the biogenic synthesis of M/MO NPs has gained massive attention due to their economical and eco-friendly nature. In the present study, Nyctanthes arbor-tristis (Nat) flower extract-derived Zinc Ferrite NPs (Nat-ZnFeO NPs) were synthesized and physicochemically characterized by FTIR, XRD, FE-SEM, DLS, and other instruments to study their crystallinity, size, shape, net charge, presence of phytocompounds on NP's surface and several other features. The average particle size of Nat-ZnFeO NPs was approx. 25.87 ± 5.67 nm. XRD results showed the crystalline nature of Nat-ZnFeO NPs. The net surface charge on NPs was -13.28 ± 7.18 mV. When tested on mouse fibroblasts and human RBCs, these NPs were biocompatible and hemocompatible. Later, these Nat-ZnFeO NPs exhibited potent anti-neoplastic activity against pancreatic, lung, and cervical cancer cells. In addition, NPs induced apoptosis in tested cancer cells through ROS generation. These in vitro studies confirmed that Nat-ZnFeO NPs could be used for cancer therapy. Moreover, further studies are recommended on ex vivo platforms for future clinical applications.

Alternate JournalAppl Biochem Biotechnol
PubMed ID37318689
PubMed Central ID5905289