TitleCRISPR/Cas based gene editing: marking a new era in medical science.
Publication TypeJournal Article
Year of Publication2021
AuthorsPrasad K, George A, Ravi NSam, Mohankumar KM
JournalMol Biol Rep
Date Published2021 May
KeywordsBiomedical Research, Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-Cas Systems, Gene Editing, Genetic Engineering, Genetic Therapy, Genome, Humans

CRISPR/Cas9 system, a bacterial adaptive immune system developed into a genome editing technology, has emerged as a powerful tool revolutionising genome engineering in all branches of biological science including agriculture, research and medicine. Rapid evolution of CRISPR/Cas9 system from the generation of double strand breaks to more advanced applications on gene regulation has made the wide-spread use of this technology possible. Medical science has benefited greatly from CRISPR/Cas9; being both a versatile and economical tool, it has brought gene therapy closer to reality. In this review, the development of CRISPR/Cas9 system, variants thereof and its application in different walks of medical science- research, diagnostics and therapy, will be discussed.

Alternate JournalMol Biol Rep
PubMed ID34143395
PubMed Central IDPMC8212587
Grant ListEMR/2017/004363 / / Science and Engineering Research Board /
2019-0916/SCR/Adhoc/BMS / / Indian Council of Medical Research /
09/1268(0002)/2019-EMR-I / / Council of Scientific and Industrial Research, India /