TitleEmergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics.
Publication TypeJournal Article
Year of Publication2021
AuthorsKumavath R, Paul S, Pavithran H, Paul MK, Ghosh P, Barh D, Azevedo V
Date Published2021 Aug 25
KeywordsAnimals, Apoptosis, Cardiac Glycosides, Clinical Trials as Topic, Humans, Molecular Docking Simulation, Neoplasms, Transcription Factors

Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well recognized and accepted in the treatment of various cardiac diseases as they can increase the rate of cardiac contractions by acting on the cellular sodium potassium ATPase pump. However, a growing number of recent efforts were focused on exploring the antitumor and antiviral potential of these compounds. Several reports suggest their antitumor properties and hence, today cardiac glycosides (CG) represent the most diversified naturally derived compounds strongly recommended for the treatment of various cancers. Mutated or dysregulated transcription factors have also gained prominence as potential therapeutic targets that can be selectively targeted. Thus, we have explored the recent advances in CGs mediated cancer scope and have considered various signaling pathways, molecular aberration, transcription factors (TFs), and oncogenic genes to highlight potential therapeutic targets in cancer management.

Alternate JournalBiomolecules
PubMed ID34572488
PubMed Central IDPMC8465509