TitleHyaluronic Acid-Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential.
Publication TypeJournal Article
Year of Publication2023
AuthorsKotla NG, Isa ILiza Mohd, Larrañaga A, Maddiboyina B, Swamy SK, Sivaraman G, Vemula PK
JournalAdv Healthc Mater
Date Published2023 Aug
KeywordsAnimals, Hyaluronan Receptors, Hyaluronic Acid, Macromolecular Substances, Mammals

In recent years, the development of hyaluronic acid or hyaluronan (HA) based scaffolds, medical devices, bioconjugate systems have expanded into a broad range of research and clinical applications. Research findings over the last two decades suggest that the abundance of HA in most mammalian tissues with distinctive biological roles and chemical simplicity for modifications have made it an attractive material with a rapidly growing global market. Besides its use as native forms, HA has received much interest on so-called "HA-bioconjugates" and "modified-HA systems". In this review, the importance of chemical modifications of HA, underlying rationale approaches, and various advancements of bioconjugate derivatives with their potential physicochemical, and pharmacological advantages are summarized. This review also highlights the current and emerging HA-based conjugates of small molecules, macromolecules, crosslinked systems, and surface coating strategies with their biological implications, including their potentials and key challenges discussed in detail.

Alternate JournalAdv Healthc Mater
PubMed ID36972409