Oxime-functionalized anti-insecticide fabric reduces insecticide exposure through dermal and nasal routes, and prevents insecticide-induced neuromuscular-dysfunction and mortality.
Title | Oxime-functionalized anti-insecticide fabric reduces insecticide exposure through dermal and nasal routes, and prevents insecticide-induced neuromuscular-dysfunction and mortality. |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Mohan MK, Thorat K, Puthiyapurayil TParassini, Sunnapu O, Chandrashekharappa S, Ravula V, Khader R, Sankaranarayanan A, Muhammad H, Vemula PKumar |
Journal | Nat Commun |
Volume | 15 |
Issue | 1 |
Pagination | 4844 |
Date Published | 2024 Jun 06 |
ISSN | 2041-1723 |
Keywords | Acetylcholinesterase, Administration, Intranasal, Animals, Carbamates, Cholinesterase Inhibitors, Insecticides, Male, Occupational Exposure, Organophosphates, Oximes, Pralidoxime Compounds, Rats, Textiles |
Abstract | Farmers from South Asian countries spray insecticides without protective gear, which leads to insecticide exposure through dermal and nasal routes. Acetylcholinesterase plays a crucial role in controlling neuromuscular function. Organophosphate and carbamate insecticides inhibit acetylcholinesterase, which leads to severe neuronal/cognitive dysfunction, breathing disorders, loss of endurance, and death. To address this issue, an Oxime-fabric is developed by covalently attaching silyl-pralidoxime to the cellulose of the fabric. The Oxime-fabric, when stitched as a bodysuit and facemask, efficiently deactivates insecticides (organophosphates and carbamates) upon contact, preventing exposure. The Oxime-fabric prevents insecticide-induced neuronal damage, neuro-muscular dysfunction, and loss of endurance. Furthermore, we observe a 100% survival rate in rats when repeatedly exposed to organophosphate-insecticide through the Oxime-fabric, while no survival is seen when organophosphate-insecticide applied directly or through normal fabric. The Oxime-fabric is washable and reusable for at least 50 cycles, providing an affordable solution to prevent insecticide-induced toxicity and lethality among farmers. |
DOI | 10.1038/s41467-024-49167-3 |
Alternate Journal | Nat Commun |
PubMed ID | 38844466 |
PubMed Central ID | PMC11156901 |