Selected Publications:

• Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library. Amy Emery, Bryn S. Hardwick, Alex T. Crooks, Nadia Milech, Paul M. Watt, Chandan Mithra, Vikrant Kumar, Saranya Giridharan, Gayathri Sadasivam, Subashini Mathivanan, Sneha Sudhakar, Sneha Bairy, Kavitha Bharatham, Manjunath A. Hurakadli, Thazhe K. Prasad, Neelagandan Kamariah, Markus Muellner, Miguel Coelho, Christopher J. Torrance, Grahame J. McKenzie, and Ashok R. Venkitaraman. Cell Chemical Biology 28, 1–14, November 18, 2021

• Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain. Kurdekar V, Giridharan S, Subbarao J, Nijaguna MB, Periasamy J, Boggaram S, Shivange AV, Sadasivam G, Padigaru M, Potluri V, Venkitaraman AR, Bharatham K ChemMedChem. 2019 Sep 18;14(18):1620-1632

• Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Periasamy J, Kurdekar V, Jasti S, Nijaguna MB, Boggaram S, Hurakadli MA, Raina D, Kurup LM, Chintha C, Manjunath K, Goyal A, Sadasivam G, Bharatham K, Padigaru M, Potluri V, Venkitaraman AR. (2018) Cell Chemical Biology 25: p. 1–14.

• Iconaru LI, Ban D, Kavitha Bharatham, Ramanathan A, Zhang W, Shelat AA, ZuoJ, Kriwacki RW “Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1)” Sci Rep. (2015) 
• Srinath Krishnamurthy, Balakrishnan Shenbaga Moorthy, Lim Xin Xiang, Lim Xin Shan, Kavitha Bharatham, Nikhil Kumar Tulsian, Ivana Mihalek, Ganesh S. Anand. “Active Site Coupling in PDE:PKA Complexes Promotes Resetting of Mammalian cAMP Signaling” Biophysical J 107 (6): 1426–1440 (2014)
• Nagakumar Bharatham, Kavitha Bharatham, Anang A. Shelat, Donald Bashford. “Drug binding mode prediction by docking: Mdm2/Mdmx inhibitors as a case study” J. Chem. Inf. Model 54(2): 648-59 (2014)
• Francis McCoy, Rashid Darbandi, Hoi Chang Lee, Kavitha Bharatham, Tudor Moldoveanu, grace Royappa, Keela Dodd, Wenwei Lin, Si-Ing Chen, Rajendra P Tangallapally, Manabu Kurokawa, Richard E. Lee, Anang Shelat, Taosheng Chen, Douglas R. Green, Robert A. Harris, Sue-Hwa Lin, Rafael A. Fissore, Roger J. Colbran, and Leta K. Nutt “Metabolic activation of CaMKII by Coenzyme A” Molecular Cell 52(3): 325-39 (2013)
• Kavitha Bharatham, Zong Hong Zhang and Ivana Mihalek. “Determinants, discriminants, conserved residues - a heuristic approach to detection of functional divergence in protein families.” PLoS ONE 6(9): e24382 (2011)
• Kavitha Bharatham, Nagakumar Bharatham, Yong Jung Kwon and K. W. Lee, “Molecular Dynamics Simulation Study on PTP1B with Allosteric Inhibitor and its Application in Receptor Based Pharmacophore Modeling” J. Computer-Aided Molecular Design 22 925-933 (2008)