@article {1935,
	title = {Biomaterials for topical and transdermal drug delivery in reconstructive transplantation.},
	journal = {Nanomedicine (Lond)},
	year = {2019},
	month = {2019 Oct 23},
	abstract = {<p>Lifelong systemic immunosuppression remains the biggest challenge in vascularized composite allotransplantation (VCA) due to the adverse effects it causes. Since VCA is a life-enhancing procedure as compared with solid organ transplant which is life-saving;\&nbsp;one needs to weigh the benefits and risks carefully. Thus, there is a huge unmet clinical need to design biomaterial-based vehicles that can deliver drugs more efficiently, topically and locally to eliminate adverse effects of systemic immune suppression. This review discusses several biomaterial-based systems that have been carefully designed, conceived and attempted to make VCA a more patient compliant approach. Variety of promising preclinical studies has shown the feasibility of the approaches, and clinical trials are required to bridge the gap. Several challenges for the future and new approaches have been discussed.</p>
},
	issn = {1748-6963},
	doi = {10.2217/nnm-2019-0137},
	author = {Dhayani, Ashish and Kalita, Sanjeeb and Mahato, Manohar and Srinath, Preethem and Vemula, Praveen K}
}
@article {1587,
	title = {Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives.},
	journal = {Adv Drug Deliv Rev},
	year = {2018},
	month = {2018 Jun 29},
	abstract = {<p>Oral colon-specific delivery systems emerged as the main therapeutic cargos by making a significant impact in the field of modern medicine for local drug delivery in intestinal inflammation. The site-specific delivery of therapeutics (aminosalicylates, glucocorticoids, biologics) to the ulcerative mucus tissue can provide prominent advantages in mucosal healing (MH). Attaining gut mucosal healing and anti-fibrosis are main treatment outcomes in inflammatory bowel disease (IBD). The pharmaceutical strategies that are commonly used to achieve a colon-specific drug delivery system include time, pH-dependent polymer coating, prodrug, colonic microbiota-activated delivery systems and a combination of these approaches. Amongst the different approaches reported, the use of biodegradable polysaccharide coated systems holds great promise in delivering drugs to the ulcerative regions. The present review focuses on major physiological gastro-intestinal tract challenges involved in altering the pharmacokinetics of delivery systems, pathophysiology of MH and fibrosis, reported drug-polysaccharide cargos and focusing on conventional to advanced disease responsive delivery strategies, highlighting their limitations and future perspectives in intestinal inflammation therapy.</p>
},
	issn = {1872-8294},
	doi = {10.1016/j.addr.2018.06.021},
	author = {Kotla, Niranjan G and Rana, Shubhasmin and Sivaraman, Gandhi and Sunnapu, Omprakash and Vemula, Praveen K and Pandit, Abhay and Rochev, Yury}
}
