TY - JOUR T1 - Derivation of iPSC lines from two patients with familial Alzheimer's disease from India. JF - Stem Cell Res Y1 - 2019 A1 - Najar, Ashaq H A1 - Sneha, K M A1 - Ashok, Aparna A1 - Babu, Swathy A1 - Subramaniam, Anand G A1 - Kannan, Ramkrishnan A1 - Viswanath, Biju A1 - Purushottam, Meera A1 - Varghese, Mathew A1 - Parvez, Suhel A1 - Panicker, Mitradas M A1 - Mukherjee, Odity A1 - Jain, Sanjeev AB -

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

VL - 34 ER -