TY - JOUR
T1 - Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India.
JF - Science
Y1 - 2021
A1 - Dhar, Mahesh S
A1 - Marwal, Robin
A1 - Vs, Radhakrishnan
A1 - Ponnusamy, Kalaiarasan
A1 - Jolly, Bani
A1 - Bhoyar, Rahul C
A1 - Sardana, Viren
A1 - Naushin, Salwa
A1 - Rophina, Mercy
A1 - Mellan, Thomas A
A1 - Mishra, Swapnil
A1 - Whittaker, Charles
A1 - Fatihi, Saman
A1 - Datta, Meena
A1 - Singh, Priyanka
A1 - Sharma, Uma
A1 - Ujjainiya, Rajat
A1 - Bhatheja, Nitin
A1 - Divakar, Mohit Kumar
A1 - Singh, Manoj K
A1 - Imran, Mohamed
A1 - Senthivel, Vigneshwar
A1 - Maurya, Ranjeet
A1 - Jha, Neha
A1 - Mehta, Priyanka
A1 - A, Vivekanand
A1 - Sharma, Pooja
A1 - Vr, Arvinden
A1 - Chaudhary, Urmila
A1 - Soni, Namita
A1 - Thukral, Lipi
A1 - Flaxman, Seth
A1 - Bhatt, Samir
A1 - Pandey, Rajesh
A1 - Dash, Debasis
A1 - Faruq, Mohammed
A1 - Lall, Hemlata
A1 - Gogia, Hema
A1 - Madan, Preeti
A1 - Kulkarni, Sanket
A1 - Chauhan, Himanshu
A1 - Sengupta, Shantanu
A1 - Kabra, Sandhya
A1 - Gupta, Ravindra K
A1 - Singh, Sujeet K
A1 - Agrawal, Anurag
A1 - Rakshit, Partha
A1 - Nandicoori, Vinay
A1 - Tallapaka, Karthik Bharadwaj
A1 - Sowpati, Divya Tej
A1 - Thangaraj, K
A1 - Bashyam, Murali Dharan
A1 - Dalal, Ashwin
A1 - Sivasubbu, Sridhar
A1 - Scaria, Vinod
A1 - Parida, Ajay
A1 - Raghav, Sunil K
A1 - Prasad, Punit
A1 - Sarin, Apurva
A1 - Mayor, Satyajit
A1 - Ramakrishnan, Uma
A1 - Palakodeti, Dasaradhi
A1 - Seshasayee, Aswin Sai Narain
A1 - Bhat, Manoj
A1 - Shouche, Yogesh
A1 - Pillai, Ajay
A1 - Dikid, Tanzin
A1 - Das, Saumitra
A1 - Maitra, Arindam
A1 - Chinnaswamy, Sreedhar
A1 - Biswas, Nidhan Kumar
A1 - Desai, Anita Sudhir
A1 - Pattabiraman, Chitra
A1 - Manjunatha, M V
A1 - Mani, Reeta S
A1 - Arunachal Udupi, Gautam
A1 - Abraham, Priya
A1 - Atul, Potdar Varsha
A1 - Cherian, Sarah S
AB - Delhi, the national capital of India, has experienced multiple SARS-CoV-2 outbreaks in 2020 and reached population seropositivity of over 50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant B.1.617.2 (Delta) replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates; ×1.5-fold, 20% reduction). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

ER -