TY - JOUR T1 - A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency. JF - Elife Y1 - 2020 A1 - Mastro, Tara L A1 - Preza, Anthony A1 - Basu, Shinjini A1 - Chattarji, Sumantra A1 - Till, Sally M A1 - Kind, Peter C A1 - Kennedy, Mary B AB -

SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.

VL - 9 ER -