%0 Journal Article %J J Clin Med %D 2019 %T The Future State of Newborn Stem Cell Banking. %A Brown, Katherine S %A Rao, Mahendra S %A Brown, Heather L %X

Newborn stem cell banking began with the establishment of cord blood banks more than 25 years ago. Over the course of nearly three decades, there has been considerable evolution in the clinical application of stem cells isolated from newborn tissues. The industry now finds itself at an inflection point as personalized medicine and regenerative medicine continue to advance. In this review, we summarize our perspective on newborn stem cell banking in the context of the future potential that stem cells from perinatal tissues are likely to play in nascent applications. Specifically, we describe the relevance of newborn stem cell banking and how the cells stored can be utilized as starting material for the next generation of advanced cellular therapies and personalized medicine.

%B J Clin Med %V 8 %8 2019 Jan 18 %G eng %N 1 %R 10.3390/jcm8010117 %0 Journal Article %J J Comput Biol %D 2019 %T INDEX-db: The Indian Exome Reference Database (Phase I). %A Ahmed P, Husayn %A V, Vidhya %A More, Ravi Prabhakar %A Viswanath, Biju %A Jain, Sanjeev %A Rao, Mahendra S %A Mukherjee, Odity %X

Deep sequencing-based genetic mapping has greatly enhanced the ability to catalog variants with plausible disease association. Confirming how these identified variants contribute to specific disease conditions, across human populations, poses the next challenge. Differential selection pressure may impact the frequency of genetic variations, and thus detection of association with disease conditions, across populations. To understand genotype to phenotype correlations, it thus becomes important to first understand the spectrum of genetic variation within a population by creating a reference map. In this study, we report the development of phase I of a new database of genetic variations called INDian EXome database (INDEX-db), from the Indian population, with an aim to establish a centralized database of integrated information. This could be useful for researchers involved in studying disease mechanisms at clinical, genetic, and cellular levels.

%B J Comput Biol %V 26 %P 225-234 %8 2019 Mar %G eng %N 3 %R 10.1089/cmb.2018.0199