%0 Journal Article %J Stem Cell Res %D 2019 %T Derivation of iPSC lines from two patients with familial Alzheimer's disease from India. %A Najar, Ashaq H %A Sneha, K M %A Ashok, Aparna %A Babu, Swathy %A Subramaniam, Anand G %A Kannan, Ramkrishnan %A Viswanath, Biju %A Purushottam, Meera %A Varghese, Mathew %A Parvez, Suhel %A Panicker, Mitradas M %A Mukherjee, Odity %A Jain, Sanjeev %X

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

%B Stem Cell Res %V 34 %P 101370 %8 2019 Jan %G eng %R 10.1016/j.scr.2018.101370