%0 Journal Article %J Stem Cell Res %D 2019 %T Characterization of new variant human ES line VH9 hESC (INSTEMe001-a): a tool for human stem cell and cancer research. %A Arasala, Radhika Rao %A Jayaram, Manjunath %A Chattai, Jagamohan %A Kumarasamy, Thangaraj %A Sambasivan, Ramkumar %A Rampalli, Shravanti %X

Human pluripotent stem cells (hPSCs) acquire changes at the genomic level upon proliferation and differentiation (Peterson and Loring, 2014). Studies from International Stem Cell Initiative and independent laboratories identified a copy number variant (CNV) in hES cell lines displaying a normal karyotype, which provided a selective advantage to hES cells in culture. In our laboratory we have identified variant H9-hESC (derived from H9-hESC) with normal karyotype, pluripotency expression, differentiation profile but with altered traits of high cell survival and low E-CADHERIN expression.

%B Stem Cell Res %V 37 %P 101444 %8 2019 May %G eng %R 10.1016/j.scr.2019.101444