Raf1, a nexus for cardiac hypertrophic signaling in human disease
In the current issue of the Journal of Molecular and Cellular Cardiology (July 2011), Dhandapany et al. further explore the ability of Raf1 to regulate hypertrophy of cardiomyocytes. The authors employ three common Raf1 mutations observed in Noonan/LEOPARD syndromes to dissect downstream signaling pathways ultimately impacting myocyte growth control.