Interactions and collaborations across our team members are strong, bringing together biochemistry, biophysics, biology, genetics, structural biology, computational biology and clinical sciences to define how the cardiomyopathy mutations affect the power output of the human heart.

The Center for Cardiovascular Biology and Disease theme in inStem focuses on genetic hypertrophic and dilated cardiomyopathies, autosomal dominant myocardial diseases caused by missense mutations in any one of the genes encoding the fundamental contractile apparatus of the heart. These diseases are common and are debilitating and often lead to sudden death. Our team is composed of six superb investigators with diverse backgrounds – John Mercer, Minhaj Sirajuddin, R. Sowdhamini, and Dhandapany Perundurai, based in Bangalore, and inStem faculty Sivaraj Sivaramakrishnan (Visiting Professor) and James Spudich (Collaborative Science Chair), based in the United States. This group brings together a team of scientists using complementary approaches to a fundamental clinical issue in India and worldwide. Interactions and collaborations across our team members are strong, bringing together biochemistry, biophysics, biology, genetics, structural biology, computational biology and clinical sciences to define how the cardiomyopathy mutations affect the power output of the human heart. Our ultimate goal is to understand the underlying molecular mechanisms of hypertrophic and dilated cardiomyopathies in order to develop new therapeutic approaches for these diseases.