TitleThe Aging Metabolome-Biomarkers to Hub Metabolites.
Publication TypeJournal Article
Year of Publication2020
AuthorsSharma R, Ramanathan A
Date Published2020 03

Aging biology is intimately associated with dysregulated metabolism, which is one of the hallmarks of aging. Aging-related pathways such as mTOR and AMPK, which are major targets of anti-aging interventions including rapamcyin, metformin, and exercise, either directly regulate or intersect with metabolic pathways. In this review, numerous candidate bio-markers of aging that have emerged using metabolomics are outlined. Metabolomics studies also reveal that not all metabolites are created equally. A set of core "hub" metabolites are emerging as central mediators of aging. The hub metabolites reviewed here are nicotinamide adenine dinucleotide, reduced nicotinamide dinucleotide phosphate, α-ketoglutarate, and β-hydroxybutyrate. These "hub" metabolites have signaling and epigenetic roles along with their canonical roles as co-factors or intermediates of carbon metabolism. Together these hub metabolites suggest a central role of the TCA cycle in signaling and metabolic dysregulation associated with aging.

Alternate JournalProteomics
PubMed ID32068959
PubMed Central IDPMC7117067
Grant ListR01 AG057353 / AG / NIA NIH HHS / United States
R01AG057353 / NH / NIH HHS / United States