The Aging Metabolome-Biomarkers to Hub Metabolites.
|Title||The Aging Metabolome-Biomarkers to Hub Metabolites.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Sharma R, Ramanathan A|
|Date Published||2020 03|
Aging biology is intimately associated with dysregulated metabolism, which is one of the hallmarks of aging. Aging-related pathways such as mTOR and AMPK, which are major targets of anti-aging interventions including rapamcyin, metformin, and exercise, either directly regulate or intersect with metabolic pathways. In this review, numerous candidate bio-markers of aging that have emerged using metabolomics are outlined. Metabolomics studies also reveal that not all metabolites are created equally. A set of core "hub" metabolites are emerging as central mediators of aging. The hub metabolites reviewed here are nicotinamide adenine dinucleotide, reduced nicotinamide dinucleotide phosphate, α-ketoglutarate, and β-hydroxybutyrate. These "hub" metabolites have signaling and epigenetic roles along with their canonical roles as co-factors or intermediates of carbon metabolism. Together these hub metabolites suggest a central role of the TCA cycle in signaling and metabolic dysregulation associated with aging.
|PubMed Central ID||PMC7117067|
|Grant List||R01 AG057353 / AG / NIA NIH HHS / United States |
R01AG057353 / NH / NIH HHS / United States