Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare.
|Title||Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Pahal S, Badnikar K, Ghate V, Bhutani U, Nayak MManjunatha, Subramanyam DNarasimhai, Vemula PKumar|
|Journal||Eur J Pharm Biopharm|
|Date Published||2021 Feb|
Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation.
|Alternate Journal||Eur J Pharm Biopharm|