TitleA sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Publication TypeJournal Article
Year of Publication2020
AuthorsMastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB
Date Published2020 Jan 15

SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.

Alternate JournalElife
PubMed ID31939740
PubMed Central IDPMC6994236
Grant ListMH15456 / MH / NIMH NIH HHS / United States
Professorship / / Allen and Lenabelle Davis Foundation /
Postdoctoral Fellowship / / National Science Foundation /
Grant 529085 / / Simons Foundation /
MR/P006213/1 / MRC_ / Medical Research Council / United Kingdom
MH15456 / MH / NIMH NIH HHS / United States
Patrick Wild Centre / / Patrick Wild Centre /