A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
|Title||A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB|
|Date Published||2020 Jan 15|
SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.
|PubMed Central ID||PMC6994236|
|Grant List||MH15456 / MH / NIMH NIH HHS / United States |
Professorship / / Allen and Lenabelle Davis Foundation /
Postdoctoral Fellowship / / National Science Foundation /
Grant 529085 / / Simons Foundation /
MR/P006213/1 / MRC_ / Medical Research Council / United Kingdom
MH15456 / MH / NIMH NIH HHS / United States
Patrick Wild Centre / / Patrick Wild Centre /