Spatial regulation and generation of diversity in signaling pathways.
|Title||Spatial regulation and generation of diversity in signaling pathways.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Saini N, Sarin A|
Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. These interactions, which are played out in micro-environments within cells and involve a relatively small number of core pathways, are the key to the development and function of multi-cellular organisms. How these outcomes are regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. This review specifically addresses spatial positioning of molecules as a means of enabling interactions and novel outcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanisms that contribute to diverse signaling outcomes.
|Alternate Journal||J Biosci|