TitleStimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.
Publication TypeJournal Article
Year of Publication2017
AuthorsLee P, Gund R, Dutta A, Pincha N, Rana I, Ghosh S, Witherden D, Kandyba E, MacLeod A, Kobielak K, Havran WL, Jamora C
Date Published2017 Dec 04

The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regeneration and repair. Using the ablation of epidermal caspase-8 as a model of wound healing in , we analyzed the signaling components responsible for epithelial stem cell proliferation. We found that IL-1α and IL-7 secreted from keratinocytes work in tandem to expand the activated population of resident epidermal γδT-cells. A downstream effect of activated γδT-cells is the preferential proliferation of hair follicle stem cells. By contrast, IL-1α-dependent stimulation of dermal fibroblasts optimally stimulates epidermal stem cell proliferation. These findings provide new mechanistic insights into the regulation and function of epidermal cell-immune cell interactions and into how components that are classically associated with inflammation can differentially influence distinct stem cell niches within a tissue.

Alternate JournalElife
PubMed ID29199946
PubMed Central IDPMC5714500
Grant ListR01 AI036964 / AI / NIAID NIH HHS / United States
T32 AI007244 / AI / NIAID NIH HHS / United States
F31 AR056593 / AR / NIAMS NIH HHS / United States
R01 AR053185 / AR / NIAMS NIH HHS / United States
/ / Wellcome Trust / United Kingdom
IA/E/13/1/501239 / / Wellcome Trust-DBT India Alliance / India
R01 AI064811 / AI / NIAID NIH HHS / United States