tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation.
|Title||tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Krishna S, Raghavan S, DasGupta R, Palakodeti D|
|Journal||Cell Mol Life Sci|
|Date Published||2021 Jan 02|
Transfer RNA (tRNA)-derived fragments (tRFs) are an emerging class of conserved small non-coding RNAs that play important roles in post-transcriptional gene regulation. High-throughput sequencing of multiple biological samples have identified heterogeneous species of tRFs with distinct functionalities. These small RNAs have garnered a lot of scientific attention due to their ubiquitous expression and versatility in regulating various biological processes. In this review, we highlight our current understanding of tRF biogenesis and their regulatory functions. We summarize the diverse modes of biogenesis through which tRFs are generated and discuss the mechanism through which different tRF species regulate gene expression and the biological implications. Finally, we conceptualize research areas that require focus to strengthen our understanding of the biogenesis and function of tRFs.
|Alternate Journal||Cell Mol Life Sci|
|Grant List||DST/SJF/LSA-02/2015-16 / / Department of Science and Technology, Ministry of Science and Technology / |
BT/PR31418/BRB/10/1758/2019 / / Department of Biotechnology , Ministry of Science and Technology /