Alterations of the epigenome by chromatin modifiers play an essential role in numerous biological processes such as development, disease and aging. The main focus of my research group is to dissect the role of histone methyltransferases, a group of chromatin modifiers in regulating cell fate commitment of somatic and stem cells. We utilize human pluripotent stem cells, somatic fibroblasts along with mouse models to address the molecular mechanisms responsible for governing decisions in differentiation in differentiation, tissue repair and aging. Such information is vital in order to understand the pathophysiology of disease and to develop novel therapeutics targeted against chromatin modifiers.

Currently we are pursuing projects determined to unravel molecular mechanisms that are responsible for cellular plasticity of somatic cells towards establishment of pluri/multipotent state and subsequently, tissue repair and aging. Our central and long-term research interest focuses on developing and applying innovative epigenetic approaches to stem cell biology and regeneration with an emphasis on translational medicine. Our team integrates expertise in epigenetics, signaling pathways and stem cell biology to address these questions.

Active Projects:

Role of histone methyltranferases in acquisition of cell fate and maintenance

The role of methyl/demethyl transferases in skin aging and tissue repair

Characterization of histone independent methylation of histone methyltransferases and its impact on biological processes.