Dr. Sunil Laxman
NUTRIENT SENSING AND METABOLIC REGULATION OF CELL FATES
Depending on the specific context, a cell can undergo different fates ranging from division, differentiation and autophagy to a commitment to cell death. My lab is interested in understanding how cell sense nutrients, and how the metabolic state of a cell can regulate distinct cell fates. Our research seeks to identify key metabolites and their sensors, and work out the signaling mechanisms through which they regulate cell fates. We are particularly interested in how cells sense and respond to amino acids. To address these questions, we combine the use of tractable genetic models, particularly but not limited to Saccharomyces cerevisiae, reconstitutive biochemical approaches, proteomics, translational profiling and quantitative metabolomics. These nutrient sensing systems hold the potential to subsequently be targeted by specific molecules (identified using chemical genetics) that can thereby regulate cell fates. You can read more about us and our research at our lab website.