Dr. Sudarshan Gadadhar was awarded the IA Intermediate Fellowship, June 2022. His program explores the “Role of tubulin posttranslational modifications in regulating primary cilia functions in wound healing and tissue homeostasis”
Mammalian primary cilia control organ functions by being a hub of key cellular signalling pathways. They are also important for proper cell migration and proliferation during tissue repair post injury/infection. Ciliary functions depend on a tightly regulated trafficking of proteins into and out of the cilia. This depends on axonemes, the microtubule-based skeleton of cilia, which are rich in tubulin posttranslational modifications, whose role in regulating cilia functions is barely known. Here we understand how different tubulin modifications regulate cilia functions and thus, organ function and tissue homeostasis.